Presence of CD151 molecules in tumor cells appears to facilitate the clustering/activation of laminin-binding (LB) integrins (α3β1, α6β1 and α6β4) on the cell surface, which in turn activates SFKs/FAK-, JAK/STAT3-, RAS/MEK- and NF-kB-dependent signaling pathways, cytoskeleton remodeling, and diverse cellular activities and behaviors [32,38,44,71,73]. The gene discussed is CD151; the disease is neoplasm.