CD151 and cancer: Furthermore, this paradigm may be originated from the cell lineage- and the oncogenic context-dependent role of CD151, highly reminiscent of its associated laminin-binding integrin α3β1 or α6β4 integrin, which seem to vary with cancer subtype or oncogenic context (inactivation/loss of tumor suppressors p53 and SMAD4 versus activation of Ras oncogene) [82,83].