CDH1 and neoplasm: In such context, loss of CD151 at cell-cell junctions leads to induction of EMT or a highly motile/invasive mesenchymal cellular phenotype featuring altered expression of typical epithelial (e.g., E-cadherin) and mesenchymal makers (e.g., vimentin, fibronectin and transcription factors Slug/Snail, etc.), enhanced tumor cell motility and invasiveness, as well as strong extracellular matrix (ECM)- arginine-glycine-aspartate (RGD) motif-binding integrin interactions [31,81].