IL5 and asthma: However, whether the levels of eotaxin, IL-5, and PGE2 in BALF or the reduction of eosinophil infiltration suggest that P. cocos extract indeed ameliorated the airway inflammation situationis Moreover, PGE2-mediated signaling has been recently reported to promote IgE levels during asthma development [31], implying that the P. cocos extract’s inhibitory effect on elevated PGE2 in BALF of asthmatic mice may attenuate asthma development via PGE2 suppression.