IGHE and allergic asthma: Moreover, Th2-secreted cytokines (IL-4, IL-5, and IL-13) further trigger a series of immune responses including eosinophilic inflammation, immunoglobulin E (IgE) expression, goblet cell hyperplasia, and airway mucus secretion [5], suggested as the most striking feature of allergic disorders, including allergic asthma [6,7].