Abnormal mitophagy was posteriorly observed in several PD models [85,86,87], but the analysis of mitophagy has to be done with extreme caution, since Rakovic and collaborators demonstrate that the mitophagy process differs between human non-neuronal and neuronal cells, and that the comparison between models with endogenous Parkin expression versus exogenous expression may be misleading [112]. The gene discussed is PRKN; the disease is Parkinson disease.