The time courses of four inflammatory mediators, namely IFN-γ, IL-6, IL-10, and TNF-α and the activities of both transaminases, i.e., ALT and AST, in the mice serum were modeled using the newly designed PK/PD/disease progression model of GRMS-55 in ConA-induced hepatitis in mice. The gene discussed is IL10; the disease is hepatitis A virus infection.