INS and Insulin resistance: The current in vitro results suggest that the simultaneous in vivo exposure of macrophages to palmitate and elevated concentrations of insulin, which result from the attempt to compensate for insulin resistance, or prostaglandin E2, which is formed in macrophages in response to palmitate and insulin, might enhance palmitate-dependent IL-8 formation and, thereby, aggravate insulin resistance and chronic adipose tissue inflammation in overweight or obese patients.