Expression patterns of CCN3 in human joints confirm the absence of CCN3 in normal hip synovium and cartilage, RA hip or RA knee cartilage and OA hip and OA knee cartilage, while CCN3 is weakly expressed in the superficial layers and matrix of RA knee and OA hip synovium samples [47]. The gene discussed is CCN3; the disease is rheumatoid arthritis.