TNF and secondary hemophagocytic lymphohistiocytosis: The The Tumor Necrosis Factor α (TNFα), Interefon γ (IFNγ), Interleukin 1 (IL-1), Interleukin 2 (IL-2) and Interleukin 6 (IL-6) areamong the cytokines significantly elevated in inflammatory diseases with pathophysiological similarities, such as COVID-19, Cytokine release syndrome, Secondary hemophagocytic lymphohistiocytosis and Immune Reconstitution Inflammatory Syndrome [20].