Interestingly, in this study, only miR-301a was found to be involved in Th17 differentiation and the pathogenesis of demyelination via Protein Inhibitor of Activated STAT 3 (PIAS3) molecule (affecting IL-6/23–STAT3 pathway) as a direct target in CD4+ T-cells. Here, PIAS3 is linked to Peripheral demyelination.