In the study, although G. elegans exhibit no significant effect on the lipid concentration in the plasma of piglets, koumine, an indole alkaloid isolated from G. elegans, significantly reduced the levels of triglycerides (TG), cholesterol (TC), low-density lipoprotein (LDL-C), alanine aminotransferase (ALT), and aspartate carbamoyl transferase (AST) in the serum of nonalcoholic fatty liver disease (NAFLD) rats [10] and increased the level of high-density lipoprotein (HDL-C). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.