MTHFR and metabolic disease: No prior disease before or during pregnancy was reported by 54 women, while 3 were carriers of the methylenetetrahydrofolate-reductase gene (MTHFR), 1 of which was in association with a PAI-1 deficit, 4 were in treatment for hypothyroidism, 5 were affected by gestational diabetes treated with a special diet (in 1 case the metabolic disease was associated with hypertension and in 1 with allergic asthma), and 6 women were affected by hypertension; finally, 2 women had developed hepatogestosis.