UBQLN2 and amyotrophic lateral sclerosis: Protein aggregation is one of the core features in both ubiquilin-2 (UBQLN2)-associated amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD) [1,2,3], a phenomenon that has been well replicated in transgenic rodents [4,5,6,7,8].