We focused on Lcn2 and Lgals3 for several reasons: (1) Lcn2 mRNA has been already found deregulated in Mecp2 KO astrocytes coming from a mouse model of RTT [17], (2) Lcn2 has been shown to modulate spine morphology and to regulate neuronal excitability [28,29] and (3) Lgals3 is strongly expressed in the brain and modulates gliogenesis and memory [30,31]. This evidence concerns the gene LCN2 and Rett syndrome.