Although information for TERT promoter mutations for this patient SANTB00442 is not available (Table 2), based on these previous antecedents, Costunolide may induce apoptosis of tumor cells through the inhibition of TERT, an effect that could have been further enhanced after chemotherapy and radiotherapy (i.e., by reduction of Nrf2 [109] in Stupp treated GBOs). This evidence concerns the gene TERT and neoplasm.