ABCB1 and cancer: Exposure to the nephrotoxic, anti-cancer drug cisplatin showed a dose-dependent disruption of the epithelial barrier, a decrease in viability, an increase in effluent lactate dehydrogenase (LDH) activity, and changes in expression of tight-junction markers and inhibition of the crucial drug efflux pumps as p-glycoprotein (p-gp) and multi-drug resistance protein (MRP) [115].