MMP14 and glaucoma: Upregulation of MMP-9 and MT1-MMP (MMP-14) gene transcripts was shown in NTG patients by RT-PCR and confirmed in the protein levels by Western-blot analysis, suggesting an increased enzymatic matrix metalloproteinase activity in these patients, and thus confirming the role of extracellular matrix and matrix metalloproteinases, the zinc-activated enzymes, in glaucoma.