TNNI3 and cardiovascular disorder: Cardiovascular diseases, including acute coronary syndrome, have been considered the globally leading cause of human death and have been gathering great attention for their early diagnosis with cardiac markers such as myoglobin [1,2,3], C-reactive protein [4,5], B-type natriuretic peptide [6,7], cardiac Troponin T [8,9], and Troponin I (cTnI) [10,11].