NFKB1 and familial pancreatic carcinoma: NF-κB pathway inhibition contributes to the pro-apoptotic effect of TTs and TFs, leading to a depletion of anti-apoptotic proteins (Bcl-2, Bcl-xL, and cFLIP) with an increase in the expression of caspases (−8, −9, and −3), pro-apoptotic protein Bax, and PARP1 (nuclear poly(ADP-ribose) polymerase 1) cleavage in pancreatic cancer tissues [81].