NFKB1 and cancer: γ-TT was found to decrease TNF-α-stimulated inducible and constitutive NF-κB activation [75], as well as STAT3 activity and its DNA binding activity in various cancer cell types (in contrast with γ-TF), which was found to be correlated with the inhibition of Src kinase and JAK1 and JAK2 kinases [76].