Eicosanoids from COXs and 5-LOX pathways contribute to cancer and metastasis development [120], so, the TF/TT-mediated inhibitory effect on COX-2 and 5-LOX was associated with cancer chemoprevention in chemically-induced/moderate colitis-promoted colon carcinogenesis [121,122] and with decreased ventral prostate epithelial dysplasia in a prostate cancer model induced by N-methyl-N-nitrosourea in rats [123]. The gene discussed is ALOX5; the disease is prostate cancer.