The simultaneous overexpression of IRX4 transcripts together with KLK3 with androgen may indicate a role of IRX4 in the early stages of PCa progression, and the antiandrogen treatment with bicalutamide and enzalutamide is not completely effective in eliminating the overexpression of IRX4 transcripts in PCa cells. The gene discussed is KLK3; the disease is posterior cortical atrophy.