IRX4 transcriptomic datasets in PCa showed a poor correlation with the proteomic data in line with recent research insights in PCa [41,61,62] due to varied discordant regulation between the transcriptional and translational regulation, post-transcriptional modifications associated with translation regulation, lack of temporal synchronization between transcription and translation and kinetic changes between protein generation and turnover in complex biological samples [63]. The gene discussed is IRX4; the disease is posterior cortical atrophy.