Although B02 and siCD81 transfection reduced nuclear Rad51 level and increased γ-H2AX in GBM cells, the levels of nuclear Rad51 and γ-H2AX foci between B02 group and B02 + siCD81 group had no significant difference at 2 h post-IR (Figure 5A and Figure 6A). This evidence concerns the gene H2AX and glioblastoma.