NFE2L2 and neoplasm: While no mention was made regarding Hippo or NFE2L2 pathway deregulation, 31% of the tumors showed whole-arm amplification of chromosome 2q, which encodes NFE2L2. Interestingly, Sekiguchi et al. identified three distinct tumor cohorts groups (E1, E2 and F) based upon the genome-wide methylation patterns of 39 of the tumors, with the E1 and E2 groups being associated with an inferior overall prognosis.