GRN and chronic obstructive pulmonary disease: In acute lung injury (ALI) and chronic obstructive pulmonary disease (COPD), miR-34b and miR-195 have been shown to regulate inflammation and proliferation by targeting progranulin (PGRN) to modulate proinflammatory cytokine production and PH domain leucine-rich repeat protein phosphatase-2 (PHLPP2), respectively, to affect Akt signaling [36,37].