IL18 and systemic lupus erythematosus: In this lupus mouse model, a continued daily administration of IL-18 resulted in renal damage exacerbation as characterized by proteinuria, glomerulonephritis, and vasculitis [18]; whereas in vivo neutralization of IL-18 attenuated glomerulonephritis and even prolonged animal survival [19], suggesting that IL-18 signalling is important for lupus and LN development.