The previously described C/EBPA and WT1 mutations exhibit different patterns of recurrency in the study presented by Masetti et al. A highly penetrant biallelic mutation of C/EBPA was revealed, and in one patient, a homozygous non-frameshift insertion was present both at diagnosis and relapse in the majority of the tumor-cell population (MF > 80%). The gene discussed is CEBPA; the disease is neoplasm.