RUNX1 and acute myeloid leukemia: Indeed, some mutations, particularly in the genes involved in DNA repair (FANC genes), telomere biology disorder (CTC1, RTEL1, WRAP53), germline myeloid neoplasm-associated genes (DDX41, RUNX1) and others such as C/EBPA and WT1, are associated with a predisposition to an earlier onset of AML and cases of familial AML [42,43,44].