SMO and breast cancer: As the activation of the Hh signaling pathway, mediated by SMO, is crucial for the maintenance of CSCs and the self-renewability of breast cancer cells [67], whereas GSK3β is positively correlated to apoptosis in the TNBC cell line (MDA) [68], the upregulation of SMO and the downregulation of GSK3β exclusively in tsMDA may contribute to higher cisplatin resistance and self-renewal ability in tsMDA, compared to tpMDA (Figure 4a,b and Figure 5).