FOXO3 and breast cancer: WFA may also operate through processes such as triggering proteinase-activated receptor 4 (PAR-4) and suppressing heat shock protein 90 (HSP90) in prostate cancer cells [10,11], obstructing nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) [12], triggering deoxyribonucleic (DNA) acid damage checkpoint (G2-M) inhibition; forkhead box O3 (FoxO3a) and apoptotic protein Bim adjustment in breast cancer [13].