A previous investigation involving an in vivo oropharyngeal candidiasis mouse model revealed that TLR2 mRNA expression in oral tissues is strongly induced by C. albicans in a sustained manner for up to 72 h after infection, whereas the TLR4 mRNA expression in oral tissues peaks at 6 h and then gradually declines until 48 h after infection [32]. This evidence concerns the gene TLR4 and infection.