MMP9 and Familial prostate cancer: We analyzed the migration of PC3 cells based on the following considerations: IL-6 may promote the initial steps of prostate cancer metastasis by upregulating MMP-9 through the PI3K/Akt signaling pathway [41], the inhibition of JAK/STAT3 activity or the interception of microtubule assembly to suppress diffuse large B-cell lymphoma migration [42]; the downregulation of STAT3 can reverse the inhibited invasion and migration of oesophageal squamous cell carcinoma [43]; and our results indicated that LASSBio-1911 and LASSBio-2208 inhibit the IL-6/STAT3 signaling pathway.