EIF2AK2 and cancer: One of these abnormalities is an enrichment of viral receptor molecules on the surface of cancer cells, which improves viral entry [2,3,4,5], while others involve defects in the cellular antiviral defense mechanisms induced by the malfunction of type I interferon pathway signaling [6,7,8], the Janus kinase (JAK)/STAT signaling pathway [9] and Protein Kinase R (PKR) activity [10,11].