Univariate Cox regression for OS identified presence of pre-therapeutic ascites, time from initial diagnosis (ID) of breast cancer to ID of metastatic liver disease, baseline bilirubin, cholinesterase, albumin, CRP, gamma-glutamyltransferase, glutamate dehydrogenase, AP, ASAT, ALAT and MP as factors with a significant impact on survival (Table 4). This evidence concerns the gene CRP and breast carcinoma.