In addition to α-amylase and immunoglobulin chains, an exclusive set of salivary proteins resulted in deregulation in the control group after the anxiety test, namely cystatin SA (CST2) and S, cysteine-rich secretory protein 3 (CRISP3), plastin-2 (LCP1), zinc-alpha-2-glycoprotein (AZGP1), leukocyte elastase inhibitor (SERPINB1), and Rho GDP-dissociation inhibitor 2 (ARHGDIB). The gene discussed is CRISP3; the disease is Anxiety.