Indeed, DCN increases MMP-2 and MMP-9 levels, reduces extracellular matrix deposition [45], and attenuates fibrotic changes in animal models of many pathological conditions, including proliferative vitreoretinopathy [46], renal fibrosis [47], and spinal cord injury [48]. The gene discussed is MMP9; the disease is CAPN5-related vitreoretinopathy.