MKI67 and neoplasm: The non-responder group had more features of tumor aggressiveness, such as advanced stage and a high Ki-67 index (responder group vs. non-responder group: stage III, 41.8% vs. 71.10%, p = 0.003; Ki-67 index ≥ 15%, 28.8% vs. 47.4%, p = 0.001) (Table 4).