Immune checkpoint blockade (ICB) targeting programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) has revolutionised the treatment of melanoma, with clinical benefit seen in up to 70% of patients when compared to either PD-1 (54%) or CTLA-4 blockade (41%) alone [1]. Here, CTLA4 is linked to melanoma.