Figure 5 also shows the increased expression of the phagocytosis-related molecules CD11b, CD68, and NG2, as well as proinflammatory phenotype-related markers CD86 and CD45 in aged microglia [147]. Nevertheless, the overall phagocytic activity of aged microglia declines, and a reduced ability to eliminate hyperactive synapses in the basal ganglia outputs may allow the motor disorders of PD to appear [148]. The gene discussed is CD68; the disease is Parkinson disease.