Furthermore, Barrett’s esophagus harbors functionally significant mutations in tumor-associated genes, such as TP53, DCC, CDKN2A, SYNE1, PRDM9, ATM, KIF2B, and PSMD11 [62], which are frequently mutated in Barrett’s adenocarcinoma [63]. This evidence concerns the gene TP53 and esophageal adenocarcinoma.