NFKB1 and esophageal adenocarcinoma: Interestingly, the transcriptional upregulation of AID induced in response to stimulation esophageal epithelial cells exposed to bile acid is mediated by the NF-κB signaling pathway, suggesting that aberrant AID expression represents the link between duodenogastric-esophageal reflux and increased susceptibility to carcinogenesis in the pathogenesis of Barrett’s esophagus [53,57].