This analysis allowed one to unveil that, compared to Tconvs, and to Tregs from spleen, tumor-infiltrating Tregs expressed a higher level of activation markers (CD44, CD71 and OX40), proliferated at a higher extent (as indicated by the higher Ki67 expression) and showed an increased mitochondrial mass (as revealed by MDR staining). Here, TNFRSF4 is linked to neoplasm.