It was also shown that following hypoxia exposure, melanoma cells bearing BRAF V600E mutation exhibit downregulation in the expression of genes encoding apoptotic regulators—BAD (Bcl-2-associated agonist of cell death) and BCL2L1 (Bcl-2-like 1, also known as Bcl-X) [39]. The gene discussed is BCL2L1; the disease is melanoma.