Elevated level of IL-8 and VEGF following GRM1 (metabotropic glutamate receptor 1)-dependent activation of AKT/mTOR (mechanistic target of rapamycin)/HIF-1 axis was also found in media derived from melanoma cells, while inhibition of GRM1 in melanoma patients led to the reduction of vasculature density in tumor specimens [66]. This evidence concerns the gene HIF1A and neoplasm.