A positive correlation between poor prognosis and the high expression of HIF-2α as well as VEGF (vascular endothelial growth factor) was observed in samples isolated from nodular malignant melanomas of the skin, while Hao et al. showed that HIF-2α overexpression induced the stemness in melanoma cells through inhibition of p21 [30]. Here, EPAS1 is linked to nodular malignant melanoma.