During the evolution in liver fibrosis, the Hepatic stellate cells (HSCs) also play a crucial role [102] through the activation and expression of several fibrosis markers such as transforming growth factor β (TGF-β), tissue inhibitor of metalloproteinases 1 and 2 (TIMP-1 and TIMP-2), and matrix metalloproteinase-2 [103]. The gene discussed is TIMP1; the disease is Hepatic fibrosis.