Different authors have reported that mixed lineage kinase 3 (MLK3) mediates the release of hepatocyte-exosomes that carry chemokine (C-X-C motif) ligand 10 (CXCL10), a macrophage chemo-attractant, with consequent activation of hepatic macrophages (Kupffer cells) during NASH and NAFLD progression [93]. This evidence concerns the gene MAP3K11 and metabolic dysfunction-associated steatotic liver disease.