However, there is evidence that, in NAFLD, mitophagy is significantly inhibited, since accumulated mitophagy intermediates, reduced AMPK activity, and increased levels of mitophagy inhibitors, such as macrophage stimulating 1 (Mst1) or Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) [251], have been observed. The gene discussed is LCLAT1; the disease is metabolic dysfunction-associated steatotic liver disease.