Therefore, using an NO signaling activator, such as ginsenoside Re or an NO donor, such as sodium nitroprusside (SNP) and S-nitroso-N-acetyl-DL-penicillamine (SNAP), could serve as a novel pharmacotherapy in the treatment of certain forms of PD and other mitophagy-related diseases by activating mitophagy, even in the absence of PINK1. Here, PINK1 is linked to Parkinson disease.