GAPDH and Huntington disease: In particular, it has been suggested that mHtt polyQ tracts interact with glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a dehydrogenase generally involved in glycolysis, resulting in a reduction in GAPDH-induced micromitophagy, a process that directly engulfs damaged mitochondria without the need of autophagosomal formation [182,184], while it has also been presumed that glycolysis might also be impaired in HD.