VCP and frontotemporal dementia: Regarding FTD, genetic studies have found mutations associated with the development of the disease in several autophagy-related genes, such as p62 [132], charged multivesicular body protein 2b (CHMP2B), a protein that is involved in the later steps of autophagy and regulates endosomal sorting [141], and Valosin-containing protein (VCP) [141,142].