Several drug resistance pathways were broadly regulated by multiple significant miRNAs found in TNBC patients, including PI3K-Akt signaling, cell cycle, EGFR tyrosine kinase inhibitor resistance (TKIs), autophagy, PD-1/PD-L1 pathway in cancer, MAPK and AMPK signaling, Wnt signaling, JAK-STAT signaling, and TGF-beta signaling. The gene discussed is EGFR; the disease is cancer.