AKT1 and neoplasm: Additionally, 4-vinylphenol isolated from H. diffusa water extract was firstly proven for its anti-angiogenic activities in Matrigel and tumor-bearing mouse models (at 0.2–2 mg/kg) as well as in human endothelial cells (at 20–40 μg/mL) via the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway [41].