CD226 and chronic myelogenous leukemia, BCR-ABL1 positive: Altogether, we found that GSK-3α appears the primary isoform restraining the expression of a subset of ligands for activating receptors such as NKG2D, NKp30 but not DNAM-1, thereby regulating the susceptibility of TKI-resistant CML cells to NK cells in vitro and in vivo.