We further investigated the involvement of c-Myc in NKG2DL regulation, given the close association of c-Myc with the PI3K/Akt pathway in Ras or oncogenic BCR-ABL1 signaling [43,44] and with the expression of ULBP1/2/3 in AML [45]. This evidence concerns the gene MYC and acute myeloid leukemia.