VEGFA and obesity due to melanocortin 4 receptor deficiency: Since angiogenesis is involved in a further high number of pathological states, such as rheumatoid arthritis, osteoarthritis, hemangioma and vascular malformation, obesity, psoriasis, new anti-angiogenic therapies are highly demanded, possibly developing additional or alternative strategies to anti-VEGF therapy whose effect is limiting in certain conditions [5].