The preventive inhibitory effect of Ac-RLYE on AMD is similar to that of another peptide inhibitor (ATWLPPR) of VEGFR-2, and it can abolish VEGF-induced angiogenesis in a rabbit corneal model [43], in which slow-releasing implants of hydrogel containing bovine serum albumin, VEGF, and/or peptide were inserted into the corneal stroma, and anti-CNV effects were assessed on day 12. This evidence concerns the gene VEGFA and age-related macular degeneration.