PRKDC and renal cell carcinoma: For example, increased expression of miR-185 makes renal cell carcinoma cells more vulnerable to radiation by regulating ATR expression at the post-transcriptional level [88], miR-874-3p targets DNA-PKcs, which also recruits and activates the downstream components in the NHEJ pathway of DSB repair [89] and miR-101 binds to both DNA-PKcs and ATM mRNAs and regulates them post-transcriptionally in various human cell lines (Figure 2) [90].