The activation of SGMS1 by 2OHOA, a synthetic hydroxylated fatty acid, modulates the lipid content of cancer cell membranes, regulates the localization of key signalling proteins, including Ras and PKC at the plasma membrane, leading to inactivation of Ras/MAPK, PI3K/Akt and PKC/cyclin/CDK signalling pathways [211]. The gene discussed is AKT1; the disease is cancer.