Through a stress response activation ONC201 is involved in EIF2α phosphorylation and increases DR5 expression [221,222] Based on the the first results using ONC201 in monotherapy which showed that the treatment was well tolerated and that ONC201 may have single agent activity in GBM [223], a phase II clinical trial was started on GBM with H3 K27M mutation (NCT02525692). Here, EIF2A is linked to glioblastoma.