However, upon the induction of DNA replication stress, a common type of stress during tumor development, the half-life of the SND1 protein was significantly reduced in AEG-1 knocked-down cells compared to the control, indicating that AEG-1–SND1 interactions are required for survival under stressful conditions, e.g., during tumor initiation [124]. The gene discussed is MTDH; the disease is neoplasm.