Increased RISC activity, granted by AEG-1 or SND1, was found to result in the increased degradation of tumor-suppressor mRNAs, which are targets of oncogenic miRNAs, including the mRNA of the tumor suppressor phosphatase and tensin homolog (PTEN), a target of miRNA-221, which is overexpressed in HCC [166]. The gene discussed is MTDH; the disease is hepatocellular carcinoma.