c-Myc is also located in chromosome 8q and is coamplified with AEG-1 in HCC patients, and a transgenic mouse with hepatocyte-specific AEG-1 and c-Myc overexpression developed highly aggressive HCC with lung metastasis, demonstrating a functional cooperation between these two molecules [122]. The gene discussed is MTDH; the disease is hepatocellular carcinoma.