LINC01638 interacts with c-Myc, protecting it from the speckle-type BTB/POZ protein (SPOP)-mediated ubiquitination and degradation, with the subsequent upregulation of AEG-1 and Twist1, promoting epithelial–mesenchymal transition (EMT) in triple-negative breast cancer cells [162]. This evidence concerns the gene SPOP and triple-negative breast carcinoma.