A recent study described the therapeutic efficacy of locked nucleic acid (LNA)-modified AEG-1 antisense oligonucleotide (ASO) in inhibiting the primary tumor growth and attenuating the metastasis of syngeneic breast, colorectal and lung tumors in C57BL/6 mice, further establishing the efficacy of a gene-based strategy for inhibiting AEG-1 [125]. Here, MTDH is linked to neoplasm.