Interestingly, SND1 is highly expressed in HCC, the SND1 overexpression increased and the SND1 knockdown-abrogated growth of human HCC xenografts in nude mice and a transgenic mouse with a hepatocyte-specific overexpression of SND1 (Alb/SND1) developed spontaneous and augmented diethylnitrosamine (DEN)-induced HCC [166,173]. Here, SND1 is linked to hepatocellular carcinoma.