MTDH and metabolic dysfunction-associated steatohepatitis: It was shown that the overexpression of AEG-1 increases the protein levels, and not mRNA levels, of multidrug resistance gene 1 (MDR1), contributing to chemoresistance, FXII, contributing to angiogenesis, and fatty acid synthase (FASN), contributing to de novo lipogenesis, hence NASH [121,130,183].