During the last two decades, a large body of studies has documented the elevated expression of AEG1 in a wide variety of cancers, including lung, breast, ovarian, endometrial, esophageal, gastric, hepatocellular, gallbladder, colorectal, prostate and renal cell carcinomas, glioma, neuroblastoma, melanoma, osteosarcoma and lymphomas and leukemias [111,112,118]. This evidence concerns the gene MTDH and central nervous system cancer.