In malignant glioma cells, the lncRNA human histocompatibility leukocyte antigen (HLA) complex P5 (HCP5) promotes malignant phenotype by upregulating Runt-related transcription factor 1 (RUNX1) via sponging miR-139, and RUNX1, in turn, upregulates AEG-1 transcription by directly binding to its promoter [161]. The gene discussed is RUNX1; the disease is malignant glioma.