CCL2 and major depressive disorder: According to the ART analysis, there were no significant differences in pre- and postoperative MCP-1 levels between patients with depression (p = 0.33; p = 0.85, respectively), cognitive impairment (p = 025; p = 022, respectively), undergoing CABG plus CVR surgery (p = 0.90 for postoperative MCP-1), and surgery with ECC (p = 0.38 for postoperative MCP-1) compared to patients without depression, without cognitive impairment, and CABG only and on-pump surgery.