In mouse and human brains, MCP-1 and its receptor (CCR2) are primarily expressed by microglia [11], and MCP-1/CCR2 signaling is involved in numerous neuroinflammatory diseases, such as multiple sclerosis [12], stroke [13], and Alzheimer’s disease (AD) [14]. The gene discussed is CCL2; the disease is early-onset autosomal dominant Alzheimer disease.