The highly significant upregulation of CRCX5, CXCL13 on all immune cells and SLAMF1 and SLAMF6 in TAMs found in our study confirms these cells as the origin of these molecules in NSCLC TME, and is suggestive of a role of these molecules in the composition of an immunosuppressive TME in NSCLC. This evidence concerns the gene SLAMF1 and non-small cell lung carcinoma.