ADORA2B and neoplasm: While some purinergic receptors and adenosine receptor ADORA2B were downregulated in CD8+ and CD4+ T cells, TAMs showed highly upregulated ADORA3, ADORA2A, and CD73. In line with our previous report, CD39 was highly expressed by both CD4+ and CD8+ T cells, as well as TAMs, derived from tumor tissue [15].