In our data, multiple receptors and other molecules in this pathway were highly regulated in tumor-infiltrating immune cells, including the adenosine receptors ADORA2B (downregulated in CD8+ TILs), ADORA3 and ADORA2A (highly upregulated in TAMs), and the ectoenzymes CD39 (upregulated in all tumor-infiltrating immune cell subsets) and CD73 (highly upregulated in TAMs). The gene discussed is CD8A; the disease is neoplasm.