In a prospective study of 6820 nondiabetic participants from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort, a higher HDL-C level, a higher HDL-C/apolipoprotein A-I (apoA-I) ratio and a higher HDL-C/apolipoprotein A-II (apoA-II) ratio were all independently associated with reduction in the risk of incident T2D [38]. This evidence concerns the gene APOA2 and type 2 diabetes mellitus.